Silica-Bound Scavengers
“Although we now have some excellent methods to effect the construction of target molecules with an ever increasing level of complexity, there is a need to find new, strategically important processes which are environmentally cleaner, more efficient and which lead to greater structural variation in a shorter period of time”
S. V. Ley et al., J. Chem. Soc., Perkin Trans. 1, 2000, 3815
What is special about solid-supported scavengers?
Silica-bound scavengers are a class of insoluble solids that are used in synthetic chemistry to capture excess reagents, catalysts, metal complexes and some by-products. The use of insoluble scavengers expedites synthesis and increases lab productivity as follows:
- Reagents and by-products can be trapped and separated by a simple filtration
- Purification protocols including chromatography and liquid-liquid extractions, which are time consuming and difficult to scale up, are not required in some cases
- One-pot multiple step reactions are more feasible to conduct
- They are suitable for use in flow-through applications and automated synthesis
For an overview on the advantages of functionalised silica gels over their polymer-supported equivalents please refer to our “silica-bound reagents”.
SiliaBond® scavengers for organic synthesis and purification
SiliCycle Inc. is a pioneer in the development of functionalised silica gels, gathered under the name SiliaBond®, for use in synthesis and purification. The backbone of all SiliaBond® products is stationary phase silica gel having particle size 40 – 63 µm and pore size 60 Å.
The following tables provide information on the SiliaBond® scavengers. All reagents and scavengers are available in Flash, SPE and 96 well plate format. Please contact us with your enquiry or to request a quote.
SiliaBond® Scavengers for Electrophiles
| Manufacturer | SiliCycle® Inc. |
| Availability | from 10 g to 25 kg |
| Particle Size | 40 - 63 µm (mesh 230 - 400) |
| Pore Size | 60 Å |
| Specific surface area | 500 m2/g |
Function to be scavenged |
Recommended SiliaBond® scavengers: |
|
Name (Product Code) |
Structure |
|
Acid chlorides
|
SiliaBond® Amine* (R52030B) |
|
SiliaBond® Diamine* (R49030B) |
|
|
SiliaBond® Triamine* (R48030B) |
 |
|
SiliaBond® DMAP (R75530B) |
 |
|
SiliaBond® Piperazine (R60030B) |
 |
|
Alkyl halides
|
SiliaBond® Thiol* (R51030B) |
|
Anhydrides
|
SiliaBond® Amine* (R52030B) |
 |
Boronic acids
|
SiliaBond® Diol (R35030B) |
 |
Carbonyl compounds
|
SiliaBond® Amine* (R52030B) |
 |
SiliaBond® Tosyl Hydrazine (R61030B) |
Captures aldehydes in the presence of ketones (latter requires acid catalysis) |
|
Chloroformates
|
SiliaBond® Amine* (R52030B) |
 |
Epoxides
|
SiliaBond® Thiol* (R51030B) |
|
Isocyanates
|
SiliaBond® Amine* (R52030B) |
 |
Sulfonyl chlorides
|
SiliaBond® Amine* (R52030B) |
 |
SiliaBond® DMAP (R75530B) |
 |
|
SiliaBond® Piperazine (R60030B) |
 |
|
* These products are also versatile metal scavengers
SiliaBond® Scavengers for Nucleophiles
| Manufacturer | SiliCycle® Inc. |
| Availability | from 10 g to 25 kg |
| Particle Size | 40 - 63 µm (mesh 230 - 400) |
| Pore Size | 60 Å |
| Specific surface area | 500 m2/g |
Function to be scavenged |
Recommended SiliaBond® scavengers: |
|
Name (Product Code) |
Structure |
|
Acids (including acidic phenols)
|
SiliaBond® Amine* (R52030B) |
 |
SiliaBond® Diamine* (R49030B) |
 |
|
SiliaBond® Triamine* (R48030B) |
 |
|
SiliaBond® Carbonate (R66030B) |
Scavenges 99% of phenylboronic acid (1 eq., after 1 h at room temperature) |
|
SiliaBond® TBD* (R68530B) |
Scavenges 98% of phenylboronic acid (1 eq., after 1 h at room temperature) |
|
Alcohols
|
SiliaBond® Tosyl Chloride (R44030B) |
 |
Alkoxides
|
SiliaBond® Isocyanate (R50030B) |
 |
SiliaBond® Carboxylic Acid (R70030B) |
 |
|
SiliaBond® Tosyl Chloride (R44030B) |
 |
|
Amines (primary and secondary)
|
SiliaBond® Isocyanate (R50030B) |
 |
SiliaBond® Propylsulfonic Acid (R51230B) |
 |
|
SiliaBond® Succinic Anhydride (R64530B) |
Offers selection over alcohols |
|
SiliaBond® Tosic Acid (R60530B) |
 |
|
SiliaBond® Tosyl Chloride (R44030B) |
 |
|
Amines (tertiary)
|
SiliaBond® Tosic Acid (R60530B) |
 |
Anilines
|
SiliaBond® Succinic Anhydride (R64530B) |
 |
SiliaBond® Tosyl Chloride (R44030B) |
 |
|
Borohydrides
|
SiliaBond® Tosic Acid (R60530B) |
 |
Hydrazines
|
SiliaBond® Isocyanate (R50030B) |
 |
SiliaBond® Tosyl Chloride (R44030B) |
 |
|
Organometallic Reagents
| SiliaBond® Carboxylic Acid (R70030B) |
 |
SiliaBond® Tosyl Chloride (R44030B) |
 |
|
Thiols
|
SiliaBond® Isocyanate (R50030B) |
 |
SiliaBond® Maleimide (R71030B) |
Immobilises peptides and proteins |
|
Thiolates
|
SiliaBond® Isocyanate (R50030B) |
 |
* These products are also versatile metal scavengers
SiliaBond® Metal Scavengers
| Manufacturer | SiliCycle® Inc. |
| Availability | from 10 g to 25 kg |
| Particle Size | 40 - 63 µm (mesh 230 - 400) |
| Pore Size | 60 Å |
| Specific surface area | 500 m2/g |
SiliaBond® scavenger |
Metal to be scavenged: |
||||||||||||||
Pd (II) |
Pd (0) |
Sn |
Zn |
Pb |
Ni (II) |
Ni (0) |
Cu |
Co |
Rh (III) |
Ru |
Cd |
Hg (II) |
Fe |
Cr (III) |
|
|
Amine (R52030B) |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
|
Diamine (R49030B) |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
Pyridine
(R43030B) |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
TAAcOH
(R69030B) |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
TAAcONa
(R69230B) |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
TBD
(R68530B) |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
Thiol (R51030B) |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
Thiourea (R69530B) |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
Triamine
(R48030B) |
• |
• |
• |
•• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• |
• Preferred scavenger
• Scavenges
• Reported in the literature or by customers
 |
 |